In vivo testing of crosslinked polyethers. I. Tissue reactions and biodegradation

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In vivo testing of crosslinked polyethers. I. Tissue reactions and biodegradation.

The in vivo biocompatibility and biodegradation of cross-linked (co)polyethers with and without tertiary hydrogen atoms in the main chain and differing in hydrophilicity were studied by means of subcutaneous implantation in rats. After 4 days, 1 month, and 3 months postimplantation, the tissue reactions and interactions were evaluated by light microscopy (LM) and transmission electron microscop...

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In vivo testing of crosslinked polyethers. II. Weight loss, IR analysis, and swelling behavior after implantation.

As reported in Part I ("In vivo testing of crosslinked polyethers. I. Tissue reactions and biodegradation," J. Biomed. Mater. Res., this issue, pp. 307-320), microscopical evaluation after implantation of crosslinked (co)polyethers in rats showed differences in the rate of biodegradation, depending on the presence of tertiary hydrogen atoms in the main chain and the hydrophilicity of the polyet...

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ژورنال

عنوان ژورنال: Journal of Biomedical Materials Research

سال: 1996

ISSN: 0021-9304,1097-4636

DOI: 10.1002/(sici)1097-4636(199611)32:3<307::aid-jbm3>3.0.co;2-w